MODEL OF SENSITIVITY CATTLE TO MASTITIS ON THE BASIS OF LYMPHOCYTIC AND MOLECULAR GENETIC MARKERS

Mastitis of cows causes significant harm to dairy farming, a susceptibility which is partly determined by genetic factors. Therefore, identifying the or resistance mastitis at an early stage postnatal ontogenesis has both practical and scientific importance. In this work, we examined model grounded on collegial use lymphocyte antigens class I MHC cattle DNA markers based alleles BoLA-DRB3 gene identify sensitivity heifers their in milking herd. On data testing 649 Ukrainian black-and-white breed, histocompatibility were revealed, statusmetric facilitated determining integral estimation sensitiveness (Z) was constructed. The greater positive Z value, higher predicted vice versa. yields 69.2% correct decisions 17 (antigens W2, W6, W31, W14, W19, W15, A9, A12, A13 A24 indicate W10, A1, A3, A6, A16, A17 A22 – disease). Some exon 2 found be associated with mastitis. For 162 from preliminary sample DRB3.2*18, *24, *26 *48 characterize mastitis, BoLA-DRB3.2*08, *13 *22 disease. A comparative analysis association DNA-markers performed comparing diagnosis, status score, presence genotype. Two four possible variants unambiguously immune cow: diagnosis score (by sign) coincide, there allele genotype that coincides established (65,7%); sign do not marker animal (13,3%). 83 animals out 105 detected, confirmed, for total 79%. accuracy predicting increased 9.8%. Following obtained results, breed postembryonic been proposed. universal can applied different breeds after appropriate research.